ActivControl® Technology: Unique Mechanism of Action Behind Real World Results

A child’s myopia diagnosis can elicit numerous questions from parents, including those centered around your prescribed treatment of MiSight® 1 day* soft contact lenses. No matter the size of your myopia control practice, these typical exam room questions likely ring familiar: How does MiSight® 1 day work? Do we really need to do this? Isn’t my child too young to wear contact lenses?

In a recent white paper, CooperVision’s Dr. Priscilla Chang details the unique and intentional design behind MiSight® 1 day, in addition to the sustained efficacy and real-world results behind MiSight®’s seven-year study. 

Here are some highlights from the paper.

MiSight® 1 day’s Innovative Design with ActivControl® Technology

MiSight® 1 day utilizes ActivControl® Technology, an optical design specifically created to simultaneously correct nearsightedness and help slow myopia progression in age-appropriate children.†1 ActivControl® Technology combines alternating treatment zones with distance correction zones. This innovative design allows children (aged 8-12 at the initiation of treatment) to enjoy the freedom from wearing glasses while helping to slow down the progression of myopia.†1

7-Year Study Illustrates Efficacy and Safety

During its initial 3-year study period, MiSight® 1 day with  ActivControl® Technology slowed the progression of myopia in children by 59% on average †1while 41% of treated eyes experienced no meaningful progression in refractive error after 3 years.‡§1 At six years, no serious contact lens related adverse events were reported.2 Finally, at the international study’s seven-year endpoint, researchers found no evidence of mean axial length rebound.◊3,4

Convenience and Comfort: Children Do Well in Contacts

Children as young as 8 years old demonstrate successful handling and confidence soon after initial fitting.¶1 Further, a survey conducted with children aged 8-12 years old who were new to contact lens wear revealed that 57% found handling MiSight® 1 day to be “kind of easy” or “really easy” after one week, which improved to 85% by 1 month.5

You can discover further highlights from the ActivControl® Technology White Paper in this one-page resource. You can also access the full ActivControl® Technology white paper here. Confidence in myopia control results is what you’re looking for.

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*Indications for use: MiSight® 1 day (omafilcon A) soft (hydrophilic) contact lenses for daily wear are indicated for the correction of myopic ametropia and for slowing the progression of myopia in children with non-diseased eyes, who at the initiation of treatment are 8-12 years of age and have a refraction of -0.75 to -4.00 diopters (spherical equivalent) with ≤ 0.75 diopters of astigmatism. The lens is to be discarded after each removal.

†Compared to a single vision 1 day lens over a 3 year period.

‡Children aged 8-12 at the initiation of treatment.

§No clinically meaningful change in refractive error -0.25D or less from baseline.

◊ Preliminary international study data shows that, on average, for children that discontinued treatment at age 14-19 following 3 or 6 years of MiSight® 1 day wear, the eye growth reverted to age-expected average myopic progression rates. Disclaimer: The stability of the myopia reduction effect 1-year post-treatment is being further evaluated in a post-approval study in the U.S. as a condition of FDA approval for MiSight 1 day.

¶Children new to contact lens wear aged 8-12, n= 130 at 1 month after dispense.

1 Chamberlain P, et al. A 3-year randomized clinical trial of MiSight® lenses for myopia control. Optom Vis Sci. 2019; 96(8):556-567.

2 Woods, J., Jones, D., Jones, L., Jones, S., Hunt, C., Chamberlain, P., & McNally, J. (2021). Ocular health of children wearing daily disposable contact lenses over a 6-year period. Contact Lens and Anterior Eye.

3 Chamberlain P, Arumugam B, et al. Myopia progression on cessation of Dual-Focus contact lens wear: MiSight 1 day 7 year findings. Optom Vis Sci 2021;98:E-abstract 210049.

4 Hammond D, Arumugam B, et al. Myopia Control Treatment Gains are Retained after Termination of Dual-focus Contact Lens Wear with no Evidence of a Rebound Effect. Optom Vis Sci 2021;98:E-abstract 215130.

5 Sulley A et al, Wearer experience and subjective responses with dual focus compared to spherical, single vision soft contact lenses in children during a 3-year clinical trial. AAO 2019 Poster Presentation.

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